Neuroscience I: Neurodevelopment

 
 

Course Goals


1. To give you a solid understanding of the experimental underpinnings of our knowledge about neurodevelopment.

2. To give you an appreciation of the different human pathologies associated with alterations in neurodevelopment


Primary Textbook: Neuroscience, 4th Edition, Purves et al.


Supplemental Readings:

The Development of the Nervous System, Sanes et al. (on E-Reserve)

Fundamental Neuroscience, Squire et al.

                                   

Electronic Media: This class will use a variety of electronic media to enhance our understanding of neuroscience. The course website has a hyperlinked version of the syllabus that allows you to connect directly to the web based media. 

“The brain is a world consisting of a number of unexplored continents and great stretches of unknown territory.”

Santiago Ramon y Cajal


Course policies, assignments, and grading can be found here


Biology 351 Fall 2008 Neurodevelopment Detailed Syllabus


October 30th  Choosing Sides: Neural Induction


  1. •Neuroscience, pp544-554; Development of the Nervous System, pp1-27

  2. •Movies:

        Xenopus Gastrulation/Neuralation (Movie) (Source: XenBase)

        Xenopus Gastrulation Cross-Section (Movie) (Source: XenBase)


November 4th  Regionalization


  1. •Neuroscience, pp554-562; Fundamental Neuroscience, pp380-385

  2. •Movies:


November 6th    Moving Away From Home: Neurogenesis, Determination and Migration

                          (Quiz 1: Induction and Regionalization)


  1. •Neuroscience, pp562-575; Development of the Nervous System, pp27-35

  2. •Movies:

         Drosophila Neuroblast Delamination (Movie) (Source:Doe Lab)

         Drosophila Neuroblast Cell Divisions (Movie) (Source:Doe Lab)

         Drosophila Asymmetric Cell Division (Movie)

         Interkinetic Nuclear Migration (Movie) (Source: Poggi et al., 2005)

         Cortical Neuron Migration (Movie) (Schmid et al. 2004)

         Neural Crest Migration (Movie) (Source)


November 11th   Looking for Your Soul Mate: Axon Pathfinding and Target Selection


  1. •Neuroscience, pp577-590

  2. •Movies:

          Lamellapodia (Movie) (Schmid et al. 2004)

          Filopodia (Movie) (Schmid et al. 2004)

          Growth Cone Repulsion (Movie) (Source: Lu and Halloran, 2005)

          Growth Cone Attraction (Movie)

          Growth Cone-Actin Dynamics (Movie) (Source:Forscher Lab)

          Growth Cone-Cytochalasin Treatment (Movie) (Source:Forscher Lab)

          Growth Cone-Microtubule Dynamics (Movie) (Source:Forscher Lab)

          Growth Cone-Target Interaction (Movie) (Source:Forscher Lab)


November 13th   Looking for Your Soul Mate: Axon Pathfinding and Target Selection

                        (Quiz 2: Neurogenesis and Pathfinding)


  1. •Neuroscience, pp577-590

  2. •Movies:

           Retinal Axon Pathfinding (Movie) (Source: Holt Lab)


November 18th:   Society for Neuroscience Meeting

                            In Class Movie: TBA

     

November 20th   Moving in Together: Synaptogenesis and Neurotrophins


  1. •Neuroscience, pp590-609


November 25th   Settling Down: Synapse Elimination and Critical Periods

                          (Quiz 3: Neurotrophins)


  1. •Neuroscience, pp611-633


November 27th    Thanksgiving Holiday


December 2nd     Synaptic Plasticity

                           Guest Lecturer: Matthew Pava 


December 4th      Final Exam Review


  1. •PRACTICE EXAM ANSWERS (doc)

  2. •Neurodevelopment Practice Exam (pdf)

  3. •Neurodevelopment Exam Review (pdf)


December 11th    Final Exam: Rm 218, 12:00--3:00 pm        


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