Course policies, assignments, and grading can be found here.
Genetics 212 Spring 2009 Detailed Syllabus
Time: 10:50 a.m. - 12:05 p.m.
Room: SCIC 123
Problem Solving Sessions: Mondays from 3:45-4:30 pm in Room 203
Fridays from 3:45-4:30 pm in Room 218
January 13th Course Introduction
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•Syllabus (pdf)
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•Introduction to the eBook
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•Introduction to GenEthics Blog
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•In Class Movie Clip: Instructions for a Human Being and Getting the Letters Out
January 15th DNA: Our Common Genetic Heritage
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•Lecture Notes (pdf)
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•Chapter 1: pp 1-15,
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•Chapter 2: pp 17-42 (Required sections highlighted and discussed in the eBook)
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•Integrative Case Study: Phenylketonuria and Cystic Fibrosis pp 156-158
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•Suggested Problems (pdf): Ch. 2: 20, 26, 31, 36
January 20th-22nd Genetic Variation: Molecular Mechanisms of Mutation
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•In Class Movie Clip: Cystic Fibrosis-Finding Cures is Hard
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•Chapter 10: pp 266-283, Table 10.5
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•Integrative Case Study: Phenylketonuria
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•Suggested Problems (pdf): Ch. 10: 16-22, 24, 25, 27
January 27th Mendelian Genetics: A Review
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•Chapter 3: pp 43-64
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•Integrative Case Study: Phenylketonuria pp 156-158
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•Suggested Problems (pdf): Ch. 3: All the end of chapter problems
January 29th Genetics Movie Night: Race - The Power of an Illusion
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•Feldman et al, (2003) A Genetic Melting pot, Nature 424: 374
February 3rd Modifications of Mendelian Genetics: From Genotype to Phenotype
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•In Class Movie Clip: Cystic Fibrosis-Complexity in Proteins
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•Chapter 5: pp 99-113, 122-124
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•Integrative Case Study: Phenylketonuria pp 156-158
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•Suggested Problems (pdf): Ch. 5:13-32
Problem Set 1 Due Before Class Begins on February 5th (pdf of Assignment)
February 5th The Genetics of Sex
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•In Class Movie Clip: Human Sex Determination-Messages in the Genes
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•Chapter 4: pp 73-91
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•Suggested Problems (pdf): Ch. 4: 17, 22-31, 35-38, 40-41
February 10th Exam 1: Material Through Feb. 3rd (Introduction to Mod. of Mendel)
February 12th Human Mendelian Traits and Pedigrees
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•Chapter 6: pp 134-142
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•Integrative Case Study: Phenylketonuria pp 156-158
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•Suggested Problems (pdf): Ch. 6: 17-26
February 17th Linkage and Recombination
February 19th Recombination and Mapping, continued
February 24th Bacterial Genetics
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•In Class Movie Clip: Resistant Tuberculosis
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•Chapter 8: pp 200-218
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•Suggested Problems (pdf): Ch. 8: 15-25
Problem Set 2 Due Before Class Begins on February 26th (pdf of the Assignment)
February 26th Viral Genetics: Bacteriophage
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•Chapter 8: pp 218-227 (not transduction)
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•Suggested Problems: Ch. 8: 26-31, 34-35
March 3rd and 5th Spring Break
March 10th Viral Genetics: Human Immunodeficiency Virus
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•In Class Movie Clip: HIV Evolution and Drug Treatment
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•Chapter 8: pp 228-230
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•“A Case for Evolutionary Thinking: Understanding HIV” (pdf)
Evolutionary Analysis, Chapter 1, by Freeman and Herron, 3rd Edition. Pp 3-17, 22-30
March 12th Exam II: Material Through Feb 24th (Modifications of Mendel to Recombination)
March 17th Viral Genetics: Avian Influenza
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•In Class Movie Clip: Pandemic Flu
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•“Flu Virus Evolution” Evolutionary Analysis, Chapter 13, Pp503-509. (Handed out in class)
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•NIAID Handout (pdf)
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•If you are interested in Avian Flu: The Nature In Focus Avian Flu Website
March 19th Transposable Elements and Evolving Genomes
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•Chapter 11 in eBook: Sections 11.5-11.7 (see annotations and notes in eBook)
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•Molecular Biology of the Cell, pp287-292 (handed out in class)
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•Suggested Problems (pdf): Ch. 11: 30-33, 35-39
Problem Set 3 Due Before Class Begins on March 31st (pdf) (Answers.pdf)
April 2nd Exam III: Material through March 24th (Bacterial Genetics to Transposons)
March 31st Molecular Mechanisms of Chromosomal Variation
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•Chapter 9: pp 237-254, Chapter 11: figure 11.19 (eBook)
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•Lupski, JR (1998) Genomic Disorders: structural features of the genome can lead to DNA rearrangements and human disease traits. TIG 14: 417-422.
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•Suggested Problems (pdf): Ch. 9: 19-21, 23 (not b, c, and g), 24, 33, 34, 37
April 7th Cancer Genetics and Pharmacogenetics
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•In Class Movie Clip: Breast Cancer-A Family Disease
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•Chapter 23 in eBook (see annotations and notes in eBook)
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•Suggested Problems (pdf): Ch 23: 21, 22, 24, 26, 27, 29, 30, 33
April 9th Sequence Variation and Forensic Genetics
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•In Class Movie Clip: DNA Databases
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•Jobling and Gill (2004) Encoded Evidence: DNA in Forensic Analysis. Nat Rev Genetics 5: 739-751
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•“Scientists Report Genetic Finding that could Aid Anthrax Inquiry”. NY Times, January 22, 2002. (Handed out in class)
April 14th Genetics Movie Night: Race-The Power of an Illusion
April 16th Mapping Mendelian Human Diseases I
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•Lecture Notes: (pdf)
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•Mapping human genes handout (pdf)
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•Practice Problems (pdf)
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•Practice Problem Answers (pdf)
Problem Set 4 Due Before Class Begins on April 21st (Problem Set 4.pdf)
April 21st Mapping Mendelian Human Diseases II
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•Lecture Notes: (pdf)
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•In Class Movie Clip: Iceland-Finding Disease Genes
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•D. Drayna. “Founder Mutations” Sci.Am. Oct 2005, pp 78-86. (pdf)
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•Integrative Case Study: Phenylketonuria
April 23rd Epigenetics
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•Lecture Notes: (pdf)
April 30th Final Exam: Exam VI (Chrom Var through Epigenetics) and Cumulative Section
Room 123, 8:00-11:00 a.m.